Eicosapentaenoic acid regulates brown adipose tissue metabolism in high-fat-fed mice and in clonal brown adipocytes
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چکیده
منابع مشابه
Salsalate activates brown adipose tissue in mice.
Salsalate improves glucose intolerance and dyslipidemia in type 2 diabetes patients, but the mechanism is still unknown. The aim of the current study was to unravel the molecular mechanisms involved in these beneficial metabolic effects of salsalate by treating mice with salsalate during and after development of high-fat diet-induced obesity. We found that salsalate attenuated and reversed high...
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Obesity represents a major risk factor for the development of several of our most common medical conditions, including Type 2 diabetes, dyslipidaemia, non-alcoholic fatty liver, cardiovascular disease and even some cancers. Although increased fat mass is the main feature of obesity, not all fat depots are created equal. Adipocytes found in white adipose tissue contain a single large lipid dropl...
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Ho, R. J. & Sutherland, E. W. (1972) J. Biol. Chem. 246, 6822-6827 Lernonnier, D., Winand. J., Furnelle, J. & Christophe, J . (1971) Diaherologia7, 328-333 Wieland, 0. ( I 957) Biochem. Z. 329, 3 13-3 I9 Winand, J. & Christophe, J. (1976) Arch. Int. P/7ysiol. Biochim. 84, 207-208 Winand, J., Furnelle, J. & Christophe, J. (1967) Bull. Soc. Chim. Biol. 49, 1845-1862 Winand, J., Furnelle, J., Wodo...
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متن کاملBrown adipose tissue activity in hypocaloric-diet fed lactating rats.
Hypocaloric diet feeding reduced the mitochondrial protein content and whole tissue GDP-binding in interscapular brown adipose tissue from both virgin and lactating rats. A reduction in brown fat lipoprotein lipase activity was also detected in underfed virgin and lactating animals. These results indicate that lactation in the rat, even though it produces a reduction in brown fat activity, does...
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ژورنال
عنوان ژورنال: The Journal of Nutritional Biochemistry
سال: 2017
ISSN: 0955-2863
DOI: 10.1016/j.jnutbio.2016.08.012